Comparison of pause predictions of two sequence-dependent transcription models
نویسندگان
چکیده
منابع مشابه
Comparison of Pause Predictions of Two Sequence-Dependent Transcription Models.
Two recent theoretical models, Bai et al. (2004, 2007) and Tadigotla et al. (2006), formulated thermodynamic explanations of sequence-dependent transcription pausing by RNA polymerase (RNAP). The two models differ in some basic assumptions and therefore make different yet overlapping predictions for pause locations, and different predictions on pause kinetics and mechanisms. Here we present a c...
متن کاملTwo transcription pause elements underlie a σ70-dependent pause cycle.
The movement of RNA polymerase (RNAP) during transcription elongation is modulated by DNA-encoded elements that cause the elongation complex to pause. One of the best-characterized pause sequences is a binding site for the σ(70) initiation factor that induces pausing at a site near lambdoid phage late-gene promoters. An essential component of this σ(70)-dependent pause is the elemental pause si...
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چکیده ندارد.
15 صفحه اولA universal transcription pause sequence is an element of initiation factor σ70-dependent pausing
The Escherichia coli σ70 initiation factor is required for a post-initiation, promoter-proximal pause essential for regulation of lambdoid phage late gene expression; potentially, σ70 acts at other sites during transcription elongation as well. The pause is induced by σ70 binding to a repeat of the promoter -10 sequence. After σ70 binding, further RNA synthesis occurs as DNA is drawn (or 'scrun...
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ژورنال
عنوان ژورنال: Journal of Statistical Mechanics: Theory and Experiment
سال: 2010
ISSN: 1742-5468
DOI: 10.1088/1742-5468/2010/12/p12007